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|
Parameter
|
Mean
|
Distribution or 95% CI
|
Source
|
|---|
|
Baseline risks
|
|
Risk of mortality
|
0.257
|
Beta (9,26)
|
ACUTE
|
|
Risk of intubation
|
0.034
|
Beta (1,28)
|
ACUTE
|
|
OR for prehospital CPAP
|
|
Base case scenario (effectiveness parameters from ACUTE)
|
|
Log (Mortality OR)
|
0.145
|
Normal (0.145, 0.521)
|
ACUTE
|
|
Log (Intubation OR)
|
0.591
|
Normal (0.591, 1.403)
|
ACUTE
|
|
Scenario using effectiveness parameters from NMA
|
|
Log (Mortality OR)
|
−0.916
|
Samples
|
ACUTE, HTA meta-analysis [2]
|
|
Log (Intubation OR)
|
−1.050
|
Samples
|
ACUTE, HTA meta-analysis [2]
|
|
Life expectancy of patients
|
|
Lifetime years
|
2.67 years
|
Normal (2.67, 0.16)
|
3CPO trial [12], Clinical opinion
|
|
Health related quality of life
|
|
Utility
|
0.6
|
Beta (640,425)
|
3CPO trial [12], Clinical opinion
|
|
Costs (in £)
|
|
Prehospital CPAP
|
£33
|
Normal (£33, £3.3)
|
O-Two/SP [13], WMAS, Expert opinion
|
|
Hospitalisation
|
£3200
|
Gamma (80,40)
|
NHS Reference Costs [14]
|
|
Intubation
|
£3600
|
Gamma (90, 40)
|
HCHS index [15], Clinical opinion
|
|
Annual costs
|
£6000
|
Gamma (60, 100)
|
3CPO trial [12], HCHS index [15], Clinical opinion
|
- HCHS Hospital and Community Health Services, WMAS West Midland Ambulance Service.
